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Palladium-catalyzed double carbonylation of propargyl amines and aryl halides to access 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones

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Abstract

In this communication, we disclosed a palladium-catalyzed carbonylative procedure for the synthesis of 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones from propargyl amines and aryl halides. By using TFBen as the CO source, the reaction provides a facile and straightforward access to various aryl-substituted 2-oxo-2,5-dihydropyrroles in good yields. The reaction mechanism is proven to be attractive as well.

Graphical abstract: Palladium-catalyzed double carbonylation of propargyl amines and aryl halides to access 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones

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Article information


Submitted
06 Jan 2020
Accepted
17 Mar 2020
First published
24 Mar 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Palladium-catalyzed double carbonylation of propargyl amines and aryl halides to access 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones

J. Ying, Z. Le, Z. Bao and X. Wu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00007H

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