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Cocrystallization with a clip-type molecule catcher: a new method to determine structures of liquid molecules

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Abstract

Single-crystal X-ray diffraction analysis is a vital and precise method to identify the structures and absolute configurations of molecules at the atomic level. However, this method is not suitable for liquid molecules. Here, we report a new and easy method to tackle this challenge via merging supramolecular chemistry and crystal engineering. A glycoluril-derived molecular clip as a molecule catcher is designed and synthesized which forms cocrystals with four different liquid molecules within 24 hours, leading to the confirmation of the structures of these liquid molecules. This work is expected to open new opportunities for the structural identification of liquid molecules.

Graphical abstract: Cocrystallization with a clip-type molecule catcher: a new method to determine structures of liquid molecules

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Article information


Submitted
26 Dec 2019
Accepted
22 Jan 2020
First published
04 Feb 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Cocrystallization with a clip-type molecule catcher: a new method to determine structures of liquid molecules

Y. Liu, P. Chen, B. Shi, T. Jiao, H. Ju, P. Liu and F. Huang, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01526D

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