Issue 3, 2020

Synthesis of unsymmetrical diarylmethanols via C–Si bond bifunctionalization enabled by sequential [1,4]-Csp2 to O-silyl migration

Abstract

Unsymmetrical C–Si bond bifunctionalization of 2,2′-bis(trimethylsilyl) diphenylmethanol has been developed via an “onoffon” sequential [1,4]-Csp2 to O-silyl migration. The approach enables installing Csp3/Csp3, Csp3/Csp2 or Csp2/Csp3 electrophiles in one pot, leading to sterically congested unsymmetrical diarylmethanols in good yields.

Graphical abstract: Synthesis of unsymmetrical diarylmethanols via C–Si bond bifunctionalization enabled by sequential [1,4]-Csp2 to O-silyl migration

Supplementary files

Article information

Article type
Research Article
Submitted
05 Dec 2019
Accepted
12 Dec 2019
First published
19 Dec 2019

Org. Chem. Front., 2020,7, 543-547

Synthesis of unsymmetrical diarylmethanols via C–Si bond bifunctionalization enabled by sequential [1,4]-Csp2 to O-silyl migration

T. Hu, L. Huang, L. Gao and Z. Song, Org. Chem. Front., 2020, 7, 543 DOI: 10.1039/C9QO01450K

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