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Issue 4, 2020
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Sulfur-directed palladium-catalyzed C(sp3)–H α-arylation of 3-pyrrolines: easy access to diverse polysubstituted pyrrolidines

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Abstract

A sulfur-directed palladium-catalyzed C(sp3)–H α-arylation of 3-pyrrolines has been disclosed by installing a thioacyl group as the directing group. The arylation reactions using arylboronic acids as coupling partners provided a variety of 2-aryl-3-pyrolines in moderate to good yields. Moreover, the α-arylated products were readily converted to various synthetically useful 3-pyrroline and pyrrolidine derivatives, especially polysubstituted pyrrolidines.

Graphical abstract: Sulfur-directed palladium-catalyzed C(sp3)–H α-arylation of 3-pyrrolines: easy access to diverse polysubstituted pyrrolidines

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Supplementary files

Article information


Submitted
02 Dec 2019
Accepted
17 Jan 2020
First published
20 Jan 2020

Org. Chem. Front., 2020,7, 666-671
Article type
Research Article

Sulfur-directed palladium-catalyzed C(sp3)–H α-arylation of 3-pyrrolines: easy access to diverse polysubstituted pyrrolidines

G. Sun, X. Zou, J. Wang and W. Yang, Org. Chem. Front., 2020, 7, 666
DOI: 10.1039/C9QO01440C

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