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Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441

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Abstract

Phomeroids A (1) and B (2), two novel meroterpenoids representing two types of skeletons, together with one known homologous analogue (3) were isolated from the deep-sea-derived fungus Phomopsis tersa FS441. Phomeroid A is the first example of tropolonic sesquiterpenes consisting of a highly fused 6/6/11/6/5/5 ring system, while phomeroid B is the first example of meroterpenoids featuring an unusual 7/6/11/6-5 spiral core skeleton. All of them showed considerable cytotoxicity against the tested cell lines, and their biosynthetic pathways were also discussed.

Graphical abstract: Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441

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Article information


Submitted
12 Nov 2019
Accepted
25 Dec 2019
First published
09 Jan 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441

S. Chen, Z. Liu, H. Tan, Y. Chen, S. Li, H. Li, S. Zhu, H. Liu and W. Zhang, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01365B

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