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Cascade cyclization reactions of alkylidenecyclopropanes for the construction of polycyclic lactams and lactones by visible light photoredox catalysis

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Abstract

A visible light photocatalytic cascade cyclization reaction of alkylidenecyclopropanes for the rapid construction of seven- and eight-membered ring-containing polycyclic lactams and lactones has been developed. The process is proposed to proceed through a radical pathway, and the suggested radical intermediate was captured by TEMPO successfully. An intermolecular version of the reaction was also achieved, affording a variety of methyl dialinoacetate products.

Graphical abstract: Cascade cyclization reactions of alkylidenecyclopropanes for the construction of polycyclic lactams and lactones by visible light photoredox catalysis

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Article information


Submitted
09 Nov 2019
Accepted
06 Dec 2019
First published
10 Dec 2019

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Cascade cyclization reactions of alkylidenecyclopropanes for the construction of polycyclic lactams and lactones by visible light photoredox catalysis

M. Chen, Y. Wei and M. Shi, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01360A

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