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Issue 2, 2020
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Spiroetherones A and B, sesquiterpene naphthoquinones, as angiogenesis inhibitors from the marine sponge Dysidea etheria

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Abstract

Spiroetherones A (1) and B (2), a pair of sesquiterpene naphthoquinones with an unprecedented “spiroetherane” carbon skeleton, were isolated from the marine sponge Dysidea etheria collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses coupled with quantum chemistry DFT GIAO 13C NMR and ECD calculations. Spiroetherone A (1) showed anti-angiogenic activity in a zebrafish model with an IC50 value of 2.4 μM. In addition, the plausible biogenetic pathway of the two metabolites is proposed.

Graphical abstract: Spiroetherones A and B, sesquiterpene naphthoquinones, as angiogenesis inhibitors from the marine sponge Dysidea etheria

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Article information


Submitted
06 Nov 2019
Accepted
06 Dec 2019
First published
09 Dec 2019

Org. Chem. Front., 2020,7, 368-373
Article type
Research Article

Spiroetherones A and B, sesquiterpene naphthoquinones, as angiogenesis inhibitors from the marine sponge Dysidea etheria

W. Jiao, Q. Xu, J. Cui, R. Shang, Y. Zhang, J. Sun, Q. Yang, K. Liu and H. Lin, Org. Chem. Front., 2020, 7, 368
DOI: 10.1039/C9QO01346F

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