A metal-free aromatic cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade is initiated by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6π-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.
S. C. Schlitzer, D. Arunprasath, K. G. Stevens and I. Sharma, Org. Chem. Front., 2020, 7, 913 DOI: 10.1039/C9QO01336A
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