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A metal-free aromatic cascade for the synthesis of diverse heterocycles

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Abstract

A metal-free aromatic cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade is initiated by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6π-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.

Graphical abstract: A metal-free aromatic cascade for the synthesis of diverse heterocycles

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Article information


Submitted
04 Nov 2019
Accepted
30 Dec 2019
First published
02 Jan 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

A metal-free aromatic cascade for the synthesis of diverse heterocycles

S. C. Schlitzer, D. Arunprasath, K. G. Stevens and I. Sharma, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01336A

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