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Issue 2, 2020
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Transition-metal free direct C–H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones

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Abstract

A practical transition-metal free decarboxylative coupling reaction of oxamic acids with quinoxalin-2(1H)-ones has been developed under mild conditions. This transformation provides an efficient approach for the preparation of 3-carbamoyl quinoxalin-2(1H)-ones, which are important subunits in biologically active natural products and medicinal chemistry. This protocol features broad substrate scope, good yields, and mild reaction conditions.

Graphical abstract: Transition-metal free direct C–H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones

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Article information


Submitted
30 Oct 2019
Accepted
26 Nov 2019
First published
27 Nov 2019

Org. Chem. Front., 2020,7, 273-285
Article type
Research Article

Transition-metal free direct C–H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones

J. Yuan, J. Zhu, H. Zhu, F. Peng, L. Yang, P. Mao, S. Zhang, Y. Li and L. Qu, Org. Chem. Front., 2020, 7, 273
DOI: 10.1039/C9QO01322A

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