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Issue 3, 2020
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A novel route to unsymmetrical disubstituted ureas and thioureas by HMPA catalyzed reductive alkylation with trichlorosilane

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Abstract

An HMPA catalyzed reductive alkylation of ureas and thioureas with trichlorosilane under mild reaction conditions has been developed. Both aldehydes and ketones could be used as efficient alkylation reagents in this method to obtain the desired products in moderate to high yields. A variety of di- and trisubsituted ureas and thioureas were easily prepared by this new reductive alkylation method. This protocol exhibits excellent functional group tolerance, chemoselectivity and practicality.

Graphical abstract: A novel route to unsymmetrical disubstituted ureas and thioureas by HMPA catalyzed reductive alkylation with trichlorosilane

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Supplementary files

Article information


Submitted
30 Oct 2019
Accepted
13 Dec 2019
First published
16 Dec 2019

Org. Chem. Front., 2020,7, 472-481
Article type
Research Article

A novel route to unsymmetrical disubstituted ureas and thioureas by HMPA catalyzed reductive alkylation with trichlorosilane

X. Ran, Y. Long, S. Yang, C. Peng, Y. Zhang, S. Qian, Z. Jiang, X. Zhang, L. Yang, Z. Wang and X. Yu, Org. Chem. Front., 2020, 7, 472
DOI: 10.1039/C9QO01321K

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