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Issue 1, 2020
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Asymmetric total synthesis of nodulisporiviridin E

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Abstract

The asymmetric total synthesis of (+)-nodulisporiviridin E, a fungal metabolite from Nodulisporium sp., was achieved in 16 steps. The synthesis features a convergent approach from two conventional fragments. An intramolecular Heck cyclization was applied to construct the C-ring and the all-carbon quaternary center at C-10. The furan E ring was installed by means of an intramolecular oxonium trapping reaction. This approach provides an advanced Michael acceptor, which might facilitate the preparation of various analogues and derivatives for biological studies.

Graphical abstract: Asymmetric total synthesis of nodulisporiviridin E

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Article information


Submitted
18 Oct 2019
Accepted
18 Nov 2019
First published
18 Nov 2019

Org. Chem. Front., 2020,7, 109-112
Article type
Research Article

Asymmetric total synthesis of nodulisporiviridin E

Y. Ji, Z. Xin, Y. Shi, H. He and S. Gao, Org. Chem. Front., 2020, 7, 109
DOI: 10.1039/C9QO01278H

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