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Issue 1, 2020
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Ni-Catalyzed electrophile driven regioselective arylative cyclization of ortho-functional diaryl acetylenes for the synthesis of pyridine and indene derivatives

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Abstract

A regioselective carbonickelation followed by cyclization, an arylative cyclization, of ortho functional diaryl acetylenes is achieved apparently through an electrophile driven alkyne polarization. A series of selectively substituted di aryl isoquinoline, pyridine and indene derivatives are thus accessed from diarylacetylenes with azide, carbonyl and cyanide tethers.

Graphical abstract: Ni-Catalyzed electrophile driven regioselective arylative cyclization of ortho-functional diaryl acetylenes for the synthesis of pyridine and indene derivatives

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Submitted
15 Oct 2019
Accepted
15 Nov 2019
First published
18 Nov 2019

Org. Chem. Front., 2020,7, 30-34
Article type
Research Article

Ni-Catalyzed electrophile driven regioselective arylative cyclization of ortho-functional diaryl acetylenes for the synthesis of pyridine and indene derivatives

M. K. R. Singam, A. Nagireddy, M. Rajesh, V. Ganesh and M. S. Reddy, Org. Chem. Front., 2020, 7, 30
DOI: 10.1039/C9QO01266D

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