Issue 1, 2020

Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides

Abstract

We have developed highly efficient fluorothiolation and difluorothiolation of alkenes under simple and mild conditions. Our fluorothiolation reagents are the commercially available Olah's reagent (Py-HF) and readily available N-thiosuccinimides. This transition metal-free system offers good chemical yields for a wide range of alkene substrates with excellent regioselectivity and good functional group tolerance.

Graphical abstract: Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides

Supplementary files

Article information

Article type
Research Article
Submitted
08 Oct 2019
Accepted
22 Nov 2019
First published
22 Nov 2019

Org. Chem. Front., 2020,7, 119-125

Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides

S. Liu, X. Zeng and B. Xu, Org. Chem. Front., 2020, 7, 119 DOI: 10.1039/C9QO01228A

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