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Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides

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Abstract

We have developed highly efficient fluorothiolation and difluorothiolation of alkenes under simple and mild conditions. Our fluorothiolation reagents are the commercially available Olah's reagent (Py-HF) and readily available N-thiosuccinimides. This transition metal-free system offers good chemical yields for a wide range of alkene substrates with excellent regioselectivity and good functional group tolerance.

Graphical abstract: Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides

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Publication details

The article was received on 08 Oct 2019, accepted on 22 Nov 2019 and first published on 22 Nov 2019


Article type: Research Article
DOI: 10.1039/C9QO01228A
Org. Chem. Front., 2020, Advance Article

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    Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides

    S. Liu, X. Zeng and B. Xu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01228A

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