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Copper-catalysed oxidative α-C(sp3)–H nitroalkylation of (hetero)arene-fused cyclic amines

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Abstract

Under aerobic copper catalysis, we herein report a direct α-C(sp3)–H nitroalkylation of N-unsubstituted (hetero)arene-fused cyclic amines with nitroalkanes. The transformation proceeds with good substrate and functional group compatibility, high step and atom efficiency, and operational simplicity.

Graphical abstract: Copper-catalysed oxidative α-C(sp3)–H nitroalkylation of (hetero)arene-fused cyclic amines

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Article information


Submitted
02 Oct 2019
Accepted
09 Dec 2019
First published
12 Dec 2019

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Copper-catalysed oxidative α-C(sp3)–H nitroalkylation of (hetero)arene-fused cyclic amines

X. Li, H. Zhao, X. Chen, H. Jiang and M. Zhang, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01208G

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