Jump to main content
Jump to site search

Issue 2, 2020
Previous Article Next Article

The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

Author affiliations

Abstract

A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic utility was further demonstrated by the facile enantioselective construction of a HIV-1 inhibitor molecule.

Graphical abstract: The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

Back to tab navigation

Supplementary files

Article information


Submitted
01 Oct 2019
Accepted
27 Nov 2019
First published
28 Nov 2019

Org. Chem. Front., 2020,7, 340-344
Article type
Research Article

The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

Y. Sun, D. Zhu, X. Rao and M. Xu, Org. Chem. Front., 2020, 7, 340
DOI: 10.1039/C9QO01203F

Social activity

Search articles by author

Spotlight

Advertisements