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The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

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Abstract

A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic utility was further demonstrated by the facile enantioselective construction of a HIV-1 inhibitor molecule.

Graphical abstract: The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

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Article information


Submitted
01 Oct 2019
Accepted
27 Nov 2019
First published
28 Nov 2019

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

Y. Sun, D. Zhu, X. Rao and M. Xu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01203F

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