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The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

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Abstract

A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic utility was further demonstrated by the facile enantioselective construction of a HIV-1 inhibitor molecule.

Graphical abstract: The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

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Publication details

The article was received on 01 Oct 2019, accepted on 27 Nov 2019 and first published on 28 Nov 2019


Article type: Research Article
DOI: 10.1039/C9QO01203F
Org. Chem. Front., 2020, Advance Article

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    The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

    Y. Sun, D. Zhu, X. Rao and M. Xu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01203F

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