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Trifluoroacetimidoyl halides: a potent synthetic origin

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Abstract

The preparation of fluorine-containing compounds has attracted considerable attention due to the important applications of their related chemicals. Among the candidates, trifluoroacetimidoyl halides are considered as potent trifluoromethyl synthons to construct a wide variety of trifluoromethyl-containing compounds and trifluoromethyl-substituted N-heterocycles, which have found extensive applications in the fields of organic synthesis, pharmaceuticals, agrochemicals, and materials science. In the review, recent advances in the synthetic applications of trifluoroacetimidoyl halides are summarized. We specially focused on two different reaction modes upon trifluoroacetimidoyl halides, namely, coupling and annulation reactions to illustrate their synthetic applications and potentials in the construction of valuable trifluoromethyl-containing molecules. Their preparations were covered as well.

Graphical abstract: Trifluoroacetimidoyl halides: a potent synthetic origin

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Article information


Submitted
22 Sep 2019
Accepted
29 Nov 2019
First published
02 Dec 2019

Org. Chem. Front., 2020, Advance Article
Article type
Review Article

Trifluoroacetimidoyl halides: a potent synthetic origin

Z. Chen, S. Hu and X. Wu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01167F

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