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Allylation of β-amino phosphonic acid precursor via palladium-NHC catalyzed allylic C–H activation

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Abstract

Allylic C–H alkylation of allylbenzene with α-cyano-phosphate ester has been achieved via Pd(II)/N-heterocyclic carbene (NHC) catalysis under mild reaction conditions and provides the corresponding linear allylation products in moderate to good yields. This reaction establishes a new method to construct β-amino phosphonic acid derivatives with tertiary phosphonates.

Graphical abstract: Allylation of β-amino phosphonic acid precursor via palladium-NHC catalyzed allylic C–H activation

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Article information


Submitted
04 Sep 2019
Accepted
30 Nov 2019
First published
02 Dec 2019

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Allylation of β-amino phosphonic acid precursor via palladium-NHC catalyzed allylic C–H activation

W. Ren, M. Jin, Q. Zuo and S. Yang, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01089K

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