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Biocompatible Artificial Tendril with Spontaneous 3D Janus Multi-helix-perversion Configuration

Abstract

A helical perversion as a singularity structure is widely seen in nature, such as climbing plant tendril, which is referred to as a kinked state connecting two helices with opposite chirality. Although previous macroscale elastic bistrip systems have been used to fabricate multiple helix-perversion structures, it is still challenging to obtain the multi-perversions in microscale. Herein, we have for the first time discovered an interesting phenomenon when PCL microcoils are assembled on PEO/PCL microstems using wet, side-by-side electrospinning which combines side-by-side electrospinning with a coaugulation bath collection. Such side-by-side electrospun Janus microfibers, upon the mismatch strain between the two jets in the coaugulation bath, are transformed into 3D multi-helix-perversion microstructures through self-scrolling. On the 3D multi-helix-perversion microstructures, the growth of HUVECs (human umbilical vein endothelial cells) are observed with a preferential cell distribution of around 86 % on the PCL microcoils. Simultaneously higher focal adhesion, enhanced cell proliferation and elongation are also exhibited on the PCL microcoils, leading to a distinctive 3D Janus cellular pattern. . Such novel 3D multi-helix-perversion microstructures hold great potential in 3D Janus biomaterials for adjustable cell patterning.

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Supplementary files

Article information


Submitted
29 Feb 2020
Accepted
13 May 2020
First published
13 May 2020

Mater. Chem. Front., 2020, Accepted Manuscript
Article type
Research Article

Biocompatible Artificial Tendril with Spontaneous 3D Janus Multi-helix-perversion Configuration

Y. Su, M. B. Taskin, M. Dong, X. Han, F. Besenbacher and M. Chen, Mater. Chem. Front., 2020, Accepted Manuscript , DOI: 10.1039/D0QM00125B

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