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pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

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Abstract

Polymerization of carbazole dicarboxaldehydes and lysine derivatives by imine and acylhydrazone formation afforded peptide-derived molecular biodynamers. Characterization of their physicochemical properties revealed an interesting morphology change upon polymerization from monomers forming submicrometer spherical micelles to nanometer-sized rigid-rod-shaped polymeric particles. A combination of light-scattering methods, small-angle neutron scattering, and transmission electron microscopy enabled a detailed investigation of this morphological change. Moreover, we investigated by dynamic and static light scattering how the pH affects the fluorescence and size of the biodynamers. These morphological and pH-dependent changes are expected to open the door to a myriad of applications of molecular biodynamers.

Graphical abstract: pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

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Article information


Submitted
22 Oct 2019
Accepted
23 Dec 2019
First published
27 Dec 2019

Mater. Chem. Front., 2020, Advance Article
Article type
Research Article

pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

S. Lee, C. Kaya, H. Jang, M. Koch, B. Loretz, E. Buhler, C. Lehr and A. K. H. Hirsch, Mater. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QM00651F

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