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Modification of proteins using olefin metathesis

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Abstract

Olefin metathesis has revolutionized synthetic approaches to carbon–carbon bond formation. With a rich history beginning in industrial settings through its advancement in academic laboratories leading to new and highly active metathesis catalysts, olefin metathesis has found use in the generation of complex natural products, the cyclization of bioactive materials, and in the polymerization of new and unique polymer architectures. Throughout this review, we will trace the deployment of olefin metathesis-based strategies for the modification of proteins, a process which has been facilitated by the extensive development of stable, isolable, and highly active transition-metal-based metathesis catalysts. We first begin by summarizing early works which detail peptide modification strategies that played a vital role in identifying stable metathesis catalysts. We then delve into protein modification using cross metathesis and finish with recent work on the generation of protein–polymer conjugates through ring-opening metathesis polymerization.

Graphical abstract: Modification of proteins using olefin metathesis

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Article information


Submitted
01 Aug 2019
Accepted
01 Jan 2020
First published
15 Jan 2020

Mater. Chem. Front., 2020, Advance Article
Article type
Review Article

Modification of proteins using olefin metathesis

M. S. Messina and H. D. Maynard, Mater. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QM00494G

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