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Issue 15, 2020
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Functional terpyridyl iron complexes for in vivo photoacoustic imaging

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Abstract

Photoacoustic (PA) imaging has received extensive attention in the recent decade due to its ultra-high resolution in deep tissue penetration, whereas functional PA probes with tunable molecular structure at a low cost level remain a significant challenge. Herein, we have rationally designed three triple-pyridyl iron complexes with different water solubilities. These complexes show a higher photothermal conversion efficiency due to their rapid excited-state deactivation, making them suitable as PA probes. Notably, the photothermal conversion efficiency of one complex named S-Fe could reach as high as 29.6%. In addition, S-Fe has excellent solubility and biocompatibility, which enable PA imaging in vivo. Significantly, further pharmacokinetics evaluation demonstrated that this complex showed minimal invasiveness for live animals and displayed a relatively fast metabolism rate. This study using inexpensive iron complexes as PA agents upgraded the toolbox for PA imaging and correlated multi-modal imaging applications.

Graphical abstract: Functional terpyridyl iron complexes for in vivo photoacoustic imaging

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Supplementary files

Article information


Submitted
20 Jan 2020
Accepted
08 Jun 2020
First published
10 Jun 2020

Inorg. Chem. Front., 2020,7, 2753-2758
Article type
Research Article

Functional terpyridyl iron complexes for in vivo photoacoustic imaging

P. Xiang, Y. Shen, J. Shen, Z. Feng, M. Sun, Q. Zhang, S. Li, D. Li, G. Zhang, Z. Wu, Y. Tian, Z. Zhang and X. Tian, Inorg. Chem. Front., 2020, 7, 2753
DOI: 10.1039/D0QI00058B

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