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A class of Pt(iv) triple-prodrugs targeting nucleic acids, thymidylate synthases and histone deacetylases

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Abstract

A series of Pt(IV) compounds comprising a special short-chain fatty acid (a histone deacetylase inhibitor) and 5-FU (a thymidylate synthase inhibitor) were prepared and bio-evaluated for their antiproliferative activity using the MTT assay. The assembled compounds 11–15, as triple-prodrugs, exhibited a potent anti-cancer activity. In particular, compounds 14 and 15 both with valproic acid (VPA) showed higher potent cytotoxicity against the tested cancer cells, whereas lower cytotoxicity toward normal human umbilical vein endothelial cells than the free drugs involved. Compound 14, as a representative for further study, rapidly enhanced the cellular accumulation in a time-dependent manner, significantly induced the DNA-damage, cell cycle blocking at the S phase, and cell apoptosis as well as suppressed migration in HeLa. Most strikingly, compound 14 simultaneously regulated the TS, HDAC and γH2AX factors, suggesting a synergistic action of 5-FU, VPA and CDDP to increase the drug effects.

Graphical abstract: A class of Pt(iv) triple-prodrugs targeting nucleic acids, thymidylate synthases and histone deacetylases

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Article information


Submitted
08 Nov 2019
Accepted
20 Jan 2020
First published
20 Jan 2020

Inorg. Chem. Front., 2020, Advance Article
Article type
Research Article

A class of Pt(IV) triple-prodrugs targeting nucleic acids, thymidylate synthases and histone deacetylases

X. Ding, R. Zhang, R. Liu, X. Song, X. Qiao, C. Xie, X. Zhao and J. Xu, Inorg. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QI01453E

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