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Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

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Abstract

Core–shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

Graphical abstract: Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

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Article information


Submitted
15 May 2020
Accepted
29 Jul 2020
First published
05 Aug 2020

This article is Open Access

Polym. Chem., 2020, Advance Article
Article type
Communication

Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

L. S. Huang, D. Le, I. Hsiao, S. Fritsch-Decker, C. Hald, S. Huang, J. Chen, J. R. Hwu, C. Weiss, M. Hsu and G. Delaittre, Polym. Chem., 2020, Advance Article , DOI: 10.1039/D0PY00710B

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