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Opposite swelling characteristics through changing the connectivity in a biopolymeric hydrogel based on glycogen and glycine

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Abstract

Glycine, a biomolecule, has been functionalized through a simple condensation reaction with one of two functional groups (–COOH and –NH2) to prepare two vinylic monomers. On the other hand, glycogen has been methacrylated (Gly-Meth) to incorporate a polymerizable vinylic group. Finally, two different hydrogels, with reversible swelling characteristics, have successfully been synthesised through polymerization of each of these two monomers with Gly-Meth. The developed hydrogels with different connectivity demonstrate a superb pH responsive sustained release behaviour of model drugs (ciprofloxacin and naproxen).

Graphical abstract: Opposite swelling characteristics through changing the connectivity in a biopolymeric hydrogel based on glycogen and glycine

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Article information


Submitted
22 Jan 2020
Accepted
15 Mar 2020
First published
16 Mar 2020

Polym. Chem., 2020, Advance Article
Article type
Communication

Opposite swelling characteristics through changing the connectivity in a biopolymeric hydrogel based on glycogen and glycine

P. Patra, N. Patra and S. Pal, Polym. Chem., 2020, Advance Article , DOI: 10.1039/D0PY00117A

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