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Issue 13, 2020
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Diselenide-crosslinked zwitterionic nanogels with dual redox-labile properties for controlled drug release

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Abstract

Drug delivery systems developed from zwitterionic polymers have intriguing antifouling properties. Combining these with stimuli-responsiveness, we fabricated a new type of zwitterionic nanogel with dual redox-labile properties by copolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and a diselenide bond-containing crosslinker through reflux precipitation polymerization. Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-based nanogels show high protein adsorption resistibility and colloidal stability at high salt concentrations. By incorporation of diselenide bonds into polymer networks, the nanogels are endowed with unique dual redox-labile properties that lead to their efficient degradation into short polymers either in a reducing environment (GSH) or in an oxidative environment (H2O2). Nanogels loaded with anticancer drugs (doxorubicin, DOX) display a finely controlled release behavior and low leakage of DOX under physiological conditions (15.0% in 24 h), but rapid and sufficient release under reducing conditions (88.3% in 24 h) or under oxidative conditions (82.2% in 24 h). Cell viability assays reveal that the blank nanogels have no cytotoxicity within a wide concentration range, while DOX-loaded nanogels present a significant inhibitive effect against tumor cells.

Graphical abstract: Diselenide-crosslinked zwitterionic nanogels with dual redox-labile properties for controlled drug release

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Supplementary files

Article information


Submitted
02 Jan 2020
Accepted
18 Feb 2020
First published
19 Feb 2020

Polym. Chem., 2020,11, 2360-2369
Article type
Paper

Diselenide-crosslinked zwitterionic nanogels with dual redox-labile properties for controlled drug release

Y. Tian, M. Lei, L. Yan and F. An, Polym. Chem., 2020, 11, 2360
DOI: 10.1039/D0PY00004C

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