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Controlling release kinetics of pH-responsive polymer nanoparticles

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Abstract

Polymers with pH-responsive properties are well-known in biomedical applications. We design here polymers that can release payloads upon acidification of their immediate environment. Various corrosion inhibitors such as benzotriazole-5-carbohydrazide, 5-(aminomethyl)-8-hydroxyquinoline, and tryptamine are conjugated to copolymers via imine or hydrazone linkages. Polymer-corrosion inhibitor conjugates displayed a faster release rate of the inhibitor under acidic conditions compared to neutral conditions. Release profiles were controlled by the type of the labile linkage, the nature of the corrosion inhibitor, and by the spacer length.

Graphical abstract: Controlling release kinetics of pH-responsive polymer nanoparticles

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Article information


Submitted
29 Dec 2019
Accepted
20 Jan 2020
First published
24 Jan 2020

Polym. Chem., 2020, Advance Article
Article type
Paper

Controlling release kinetics of pH-responsive polymer nanoparticles

N. Dararatana, F. Seidi, J. Hamel and D. Crespy, Polym. Chem., 2020, Advance Article , DOI: 10.1039/C9PY01946D

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