Issue 10, 2020

Pushing the limits of single chain compaction analysis by observing specific size reductions via high resolution mass spectrometry

Abstract

Herein, we push the limits of single chain nanoparticle (SCNP) analysis to directly observe the specific compaction of defined single chains dependent on the number of compaction steps utilizing a copolymer consisting of styrene and chloromethylstyrene, compacted via Friedel–Crafts alkylation. Our study critically expands the boundaries of SCNP characterization via size exclusion chromatography coupled with high resolution electrospray ionization mass spectrometry (SEC-ESI-MS), highlighting the unique compositional and structural information that can be derived via this technique.

Graphical abstract: Pushing the limits of single chain compaction analysis by observing specific size reductions via high resolution mass spectrometry

Supplementary files

Article information

Article type
Communication
Submitted
20 Dec 2019
Accepted
07 Feb 2020
First published
07 Feb 2020

Polym. Chem., 2020,11, 1696-1701

Pushing the limits of single chain compaction analysis by observing specific size reductions via high resolution mass spectrometry

T. Nitsche, S. J. Blanksby, J. P. Blinco and C. Barner-Kowollik, Polym. Chem., 2020, 11, 1696 DOI: 10.1039/C9PY01910C

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