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Synthesis of Surface Functionalized Hollow Microporous Organic Capsules for Doxorubicin Delivery to Cancer Cells

Abstract

Functionalized hypercrosslinked polymers have presented potential applications in various fields and highly potent in bio-medical applications. Irrespective of random morphology, hypercrosslinked polymers with a spherical and hollow capsular shape are worthy in terms of fabrication and functionalization. Based on the appealing performance of polymeric capsules, herein we report the synthesis of folate-functionalized biocompatible hollow capsules that have a decent potential for the delivery of anticancer drug specifically to the cancer cells. The pyrene units are incorporated in these capsules to further enhance their scope for imaging applications. To improve the targeting efficiency, the folic acid was conjugated to the surface of hollow microporous organic capsules (HMOCs-FA) via a facile strategy using SiO2 nanoparticles as templates and the covalent attachment of FA on the surface of capsules. These microporpous organic capsules exhibit high surface area up to 700 m2g-1 and maximum encapsulation drug efficiency of up to 86 %. Moreover, the HMOCS-FA capsules are highly biocompatible and show the internalization in to MCF-7 and MDA-MB-231 cell lines via folate receptor mediated endocytosis.

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Article information


Submitted
24 Nov 2019
Accepted
20 Jan 2020
First published
22 Jan 2020

Polym. Chem., 2020, Accepted Manuscript
Article type
Paper

Synthesis of Surface Functionalized Hollow Microporous Organic Capsules for Doxorubicin Delivery to Cancer Cells

S. Razzaque, Y. Cheng, I. Hussain and B. Tan, Polym. Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9PY01772K

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