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Synthesis and self-assembly of polyethersulfone-based amphiphilic block copolymers as microparticles for suspension immunosensors

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Abstract

Polyethersulfone (PES) is one of the most widely used high-performance polymers in biomedicine due to its unique combination of mechanical properties and biocompatibility. However, the intrinsic hydrophobicity of PES hinders its biomedical application efficiency because of biofouling or non-specific adsorption concerns, which could be mitigated by introducing hydrophilic moieties into PES. In this work, we have synthesized, for the first time, a novel amphiphilic block copolymer named as amPENS containing both the hydrophobic PES segment and the hydrophilic polyarylene ether nitrile (PEN) segment. Furthermore, the synthesized amPENS has been transformed into sub-micrometer-sized microparticles via the emulsion solvent evaporation-induced self-assembly, and the size as well as fine morphology of the obtained PENS microparticles can be readily modulated by varying different experimental parameters. Finally, as a proof-of-concept application, the monoclonal antibody against insulin has been covalently immobilized on the surface of the optimized PENS microparticles, which allows specific qualitative discrimination of insulin in a suspension immunoassay via flow cytometry.

Graphical abstract: Synthesis and self-assembly of polyethersulfone-based amphiphilic block copolymers as microparticles for suspension immunosensors

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Article information


Submitted
11 Nov 2019
Accepted
03 Jan 2020
First published
06 Jan 2020

Polym. Chem., 2020, Advance Article
Article type
Paper

Synthesis and self-assembly of polyethersulfone-based amphiphilic block copolymers as microparticles for suspension immunosensors

W. Hu, X. He, Y. Bai, L. Zheng, Y. Hu, P. Wang, X. Liu and K. Jia, Polym. Chem., 2020, Advance Article , DOI: 10.1039/C9PY01701A

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