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Multicomponent polymerization toward biodegradable polymers with diverse responsiveness in tumor microenvironments

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Abstract

Multicomponent polymerization (MCP), as a powerful synthetic tool, has been widely utilized to prepare diverse functional polymers for optical, electronic, and biomedical applications. Here, a Cu(I)-catalyzed MCP toward biodegradable polymers with diverse responsiveness in tumor microenvironments (TMEs) is developed using diynes, sulfonyl azides and a series of TME-responsive, cleavable diols. The resulting polymers showed high molecular weights (up to 12000 g mol−1) and high yields (up to 96%). The biodegradable polymers displayed excellent degradation performance in various simulated TMEs (reactive oxygen species, high reducing reagent, and low pH). One typical photosensitizer, tetraphenyl porphyrin (TPP), was conjugated to the side chains of the polymers for potential application in photodynamic therapy (PDT). The TPP-polymer conjugates displayed enhanced fluorescence intensity and higher singlet oxygen quantum yield than the TPP monomer due to the controlled conjugation efficiency and the unique MCP structure, which provided a complementary strategy to limit the undesired aggregation-caused-quenching (ACQ) effect of PDT.

Graphical abstract: Multicomponent polymerization toward biodegradable polymers with diverse responsiveness in tumor microenvironments

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Article information


Submitted
19 Oct 2019
Accepted
22 Dec 2019
First published
23 Dec 2019

Polym. Chem., 2020, Advance Article
Article type
Paper

Multicomponent polymerization toward biodegradable polymers with diverse responsiveness in tumor microenvironments

J. He, N. Zheng, D. Xie, Y. Zheng and W. Song, Polym. Chem., 2020, Advance Article , DOI: 10.1039/C9PY01576K

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