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PCR-RAFT: rapid high throughput oxygen tolerant RAFT polymer synthesis in a biology laboratory

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Abstract

Some of the main applications for synthetic polymers are found within the medical field (drug delivery, diagnostics, medical imaging). However, preparation of these macromolecules has been limited to those with access to chemistry facilities, potentially delaying biological evaluation. In this work, we aim to address this issue by utilising equipment typically found within a biological lab to establish a protocol for the preparation of well-defined macromolecules via RAFT polymerisation. By exploiting thermocycler technology, libraries of homopolymers, block- and statistical-copolymers were prepared in under 5 minutes per heating cycle using acrylamide monomers with ultrafast RAFT polymerisation. All the polymers prepared had excellent molar mass control and could be generated in under 15 min.

Graphical abstract: PCR-RAFT: rapid high throughput oxygen tolerant RAFT polymer synthesis in a biology laboratory

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Article information


Submitted
08 Oct 2019
Accepted
09 Dec 2019
First published
11 Dec 2019

Polym. Chem., 2020, Advance Article
Article type
Paper

PCR-RAFT: rapid high throughput oxygen tolerant RAFT polymer synthesis in a biology laboratory

P. Gurnani, T. Floyd, J. Tanaka, C. Stubbs, D. Lester, C. Sanchez-Cano and S. Perrier, Polym. Chem., 2020, Advance Article , DOI: 10.1039/C9PY01521C

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