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Functionalization-induced self-assembly under ambient conditions via thiol-epoxide “click” chemistry

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Abstract

Polymer micelles were formed using thiol-epoxide “click” chemistry to trigger functionalization-induced self-assembly (FISA) of block copolymers by modifying a reactive glycidyl methacrylate block with solvophobes. Ambient conditions, polymer concentrations up to 10 wt%, and an array of functional thiols were found effective for nanoparticle synthesis. Real-time analysis enabled direct observation of the self-assembly process, revealing mechanistic details and a critical degree of functionalization required for micellization.

Graphical abstract: Functionalization-induced self-assembly under ambient conditions via thiol-epoxide “click” chemistry

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Publication details

The article was received on 31 Jul 2019, accepted on 14 Oct 2019 and first published on 21 Oct 2019


Article type: Communication
DOI: 10.1039/C9PY01144G
Polym. Chem., 2020, Advance Article

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    Functionalization-induced self-assembly under ambient conditions via thiol-epoxide “click” chemistry

    D. H. Howe, K. J. Jenewein, J. L. Hart, M. L. Taheri and A. J. D. Magenau, Polym. Chem., 2020, Advance Article , DOI: 10.1039/C9PY01144G

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