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Tuning chromatic response, sensitivity, and specificity of polydiacetylene-based sensors

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Abstract

Polydiacetylenes (PDAs) are a class of conjugated polymers with unique optical properties that make them excellent materials for the construction of colorimetric sensors. Self-assembly of amphiphilic diacetylene monomers in solution and photopolymerization of neighboring diacetylene groups yield blue-phase PDAs. PDAs can be functionalized with a wide range of recognition elements, and chemical and biological recognition events, e.g. protein-antibody interaction, nucleic acid hybridization, pH change, can generate a visible blue-to-red chromatic transition of PDA. The color change mechanism remains to be fully elucidated and is analyte dependent, and its understanding is key to optimizing PDA-based sensing systems. In this review, we provide an overview of different methods of tuning the chromatic response, sensitivity, and specificity of PDA-based sensors. It draws conclusions regarding the relationship between these variables, specifically sensitivity and specificity, to guide the future development of PDA sensing systems.

Graphical abstract: Tuning chromatic response, sensitivity, and specificity of polydiacetylene-based sensors

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Publication details

The article was received on 28 Jun 2019, accepted on 18 Aug 2019 and first published on 20 Aug 2019


Article type: Review Article
DOI: 10.1039/C9PY00949C
Polym. Chem., 2020, Advance Article

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    Tuning chromatic response, sensitivity, and specificity of polydiacetylene-based sensors

    M. Weston, A. D. Tjandra and R. Chandrawati, Polym. Chem., 2020, Advance Article , DOI: 10.1039/C9PY00949C

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