Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Effect of linker length on photo-cross-linking position mediated by click chemistry via [2 + 2]photocycloaddition

Author affiliations

Abstract

Ultrafast reversible DNA/RNA photo-cross-linking is a powerful tool for regulating the target strand in living cells. In particular, 3-cyanovinylcarbazole (CNVK) and 3-cyanovinylcarbazole modified by D-threoninol (CNVD) can photo-cross-link to pyrimidine bases within a few seconds of photoirradiation. However, these photo-cross-linkers can only cross-link to the counter base if it is adjacent to the 5′-side (−1 position). In this study, we synthesized novel photo-cross-linkers with varying linker lengths capable of photo-cross-linking with pyrimidine bases at locations other than the −1 position via click chemistry. The photo-cross-linking site was dependent on linker length.

Graphical abstract: Effect of linker length on photo-cross-linking position mediated by click chemistry via [2 + 2]photocycloaddition

Back to tab navigation

Supplementary files

Article information


Submitted
16 Mar 2020
Accepted
12 May 2020
First published
19 May 2020

Photochem. Photobiol. Sci., 2020, Advance Article
Article type
Communication

Effect of linker length on photo-cross-linking position mediated by click chemistry via [2 + 2]photocycloaddition

K. Fujimoto, K. Ishida, L. Xue and S. Nakamura, Photochem. Photobiol. Sci., 2020, Advance Article , DOI: 10.1039/D0PP00098A

Social activity

Search articles by author

Spotlight

Advertisements