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Photochromic meta-diamides for optical modulation of ligand activity and neuron function

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Abstract

Photopharmacology offers facile solutions for spatiotemporal control over ligand activity and receptor function. The meta-diamide insecticide acts on insect GABA receptors (GABARs) as an antagonist that causes firing of a neuron. We present here photochromic GABAR ligands azobenzene-meta-diamides (ABMDAs) by incorporating photoswitchable azobenzene with meta-diamides. ABMDAs showed good isomerization efficiency and fatigue resistance. Among them, ABMDA7 shows a 1.5-fold insecticidal activity difference towards mosquito larvae (Aedes albopictus) before and after UV illumination. We translated this light-dependent activity difference to the optical modulation of the membrane potential of American cockroach (Periplaneta americana) DUM neurons. This light-responsive meta-diamide-based GABAR ligand allows for optical regulation of insecticidal activity and DUM neurons.

Graphical abstract: Photochromic meta-diamides for optical modulation of ligand activity and neuron function

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Supplementary files

Article information


Submitted
11 Feb 2020
Accepted
28 Apr 2020
First published
01 May 2020

Photochem. Photobiol. Sci., 2020, Advance Article
Article type
Paper

Photochromic meta-diamides for optical modulation of ligand activity and neuron function

C. Zhou, Y. Ji, L. Ren and X. Shao, Photochem. Photobiol. Sci., 2020, Advance Article , DOI: 10.1039/D0PP00045K

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