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Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

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Abstract

We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product 1O2 close to the amyloid superstructures, resulting in AF decomposition.

Graphical abstract: Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

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Article information


Submitted
28 Aug 2019
Accepted
06 Jan 2020
First published
14 Jan 2020

Photochem. Photobiol. Sci., 2020, Advance Article
Article type
Communication

Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

T. Harada, H. Matsuzaki, R. Oyama, T. Takeuchi, T. Takei, T. Ninomiya, K. Takami, T. Inoue, H. Nishiguchi, E. Hifumi, H. Shinto, H. Takahashi and K. Umemura, Photochem. Photobiol. Sci., 2020, Advance Article , DOI: 10.1039/C9PP00356H

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