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Conversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions

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Abstract

Here, we used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles from simple and inexpensive raw materials. Further diversification of the 2-nitrobenzonitrile product was performed to highlight the practicality of the protocols.

Graphical abstract: Conversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions

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Article information


Submitted
22 Sep 2020
Accepted
06 Oct 2020
First published
07 Oct 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Conversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions

Z. Fu, X. Cao, S. Wang, S. Guo and H. Cai, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01945C

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