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Total synthesis of thioamycolamide A via a biomimetic route

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Abstract

Thioamycolamide A is a biosynthetically unique cytotoxic cyclic microbial lipopeptide that bears a D-configured thiazoline, a thioether bridge, a fatty acid side chain, and a reduced C-terminus. Based on the biosynthetic insights, a concise total synthesis of thioamycolamide A was accomplished.

Graphical abstract: Total synthesis of thioamycolamide A via a biomimetic route

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Article information


Submitted
22 Sep 2020
Accepted
05 Oct 2020
First published
08 Oct 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Total synthesis of thioamycolamide A via a biomimetic route

C. Pan, T. Kuranaga and H. Kakeya, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01942A

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