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Ruthenium-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles via C–H/N–H bond functionalizations

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Abstract

An efficient method for the construction of various pyrazolo[5,1-a]isoquinolines has been achieved via Ru(II)-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles. This oxidant-free transformation occurred through pyrazole-directed C–H activation, Ru-carbene insertion, and acid-promoted carbonyl condensation processes, enabling dual C–C and C–N bond formation. A broad substrate scope with respect to both coupling components worked efficiently with high yields.

Graphical abstract: Ruthenium-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles via C–H/N–H bond functionalizations

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Article information


Submitted
15 Sep 2020
Accepted
09 Oct 2020
First published
09 Oct 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Ruthenium-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles via C–H/N–H bond functionalizations

Z. Chen, Z. Ding, T. Chen, L. Meng and G. Wang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01899F

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