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Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1

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Abstract

Two new unique angucyclinones (1 and 2) with unprecedented ether bridges connecting carbons 5 and 7 were isolated from the cultures of Streptomyces bulli GJA1, an endophyte of Gardenia jasminoides, together with two known ones (3 and 4). The MS2-based molecular networking system facilitated the isolation of compounds with target functionalities. The stereochemistry of 1 was completely established by ROESY and ECD experiments. Compound 3 showed antivirulence activities by inhibiting the peptide toxin (PSMs) production and the biofilm formation of MRSA. Compounds 3 and 4 showed very potent anti-proliferative effects against OV1 and ES2 ovarian cancer cells.

Graphical abstract: Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1

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Article information


Submitted
08 Sep 2020
Accepted
25 Sep 2020
First published
30 Sep 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1

J. W. Kim, Y. Kwon, S. Bang, H. E. Kwon, S. Park, Y. Lee, S. T. Deyrup, G. Song, D. Lee, H. Joo and S. H. Shim, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01851A

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