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Issue 40, 2020
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Acid-promoted synthesis and photophysical properties of substituted acridine derivatives

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Abstract

A simple and efficient synthetic protocol for the preparation of acridinium esters and amides through the cyclization and esterification or amidation of isatins with alcohols or amines as nucleophiles in the presence of CF3SO3H is established. A series of polycyclic acridine derivatives bearing large π-conjugated systems were obtained in high yields, including some key intermediates for the synthesis of biologically active molecules. The photophysical properties of these synthesized acridines were investigated, demonstrating that the sulfur heterocyclic acridine 9w was obtained in a high quantum yield.

Graphical abstract: Acid-promoted synthesis and photophysical properties of substituted acridine derivatives

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Supplementary files

Article information


Submitted
03 Sep 2020
Accepted
24 Sep 2020
First published
24 Sep 2020

Org. Biomol. Chem., 2020,18, 8141-8146
Article type
Paper

Acid-promoted synthesis and photophysical properties of substituted acridine derivatives

Z. Bian, X. Lv, Y. Li, W. Sun, J. Liu and B. Wu, Org. Biomol. Chem., 2020, 18, 8141
DOI: 10.1039/D0OB01824D

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