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Rhodium-catalyzed synthesis of substituted isoquinolones via a selective decarbonylation/alkyne insertion cascade of phthalimides

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Abstract

A rhodium-catalyzed decarbonylation/alkyne insertion cascade of phthalimides has been established. The reaction can be carried out in an operationally simple manner and provides expedient access to a series of isoquinolones in moderate to good yields. This reaction proceeded through a sequential decarbonylation/alkyne insertion/intramolecular annulation procedure and featured good functional group tolerance, ample substrate scope, and the construction of C–C and C–N bonds in one pot.

Graphical abstract: Rhodium-catalyzed synthesis of substituted isoquinolones via a selective decarbonylation/alkyne insertion cascade of phthalimides

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Supplementary files

Article information


Submitted
30 Aug 2020
Accepted
02 Oct 2020
First published
05 Oct 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Rhodium-catalyzed synthesis of substituted isoquinolones via a selective decarbonylation/alkyne insertion cascade of phthalimides

F. Xu, W. Zhu, J. Wang, Q. Ma and L. Shen, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01793K

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