Jump to main content
Jump to site search


FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities

Author affiliations

Abstract

There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.

Graphical abstract: FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities

Back to tab navigation

Supplementary files

Article information


Submitted
29 Aug 2020
Accepted
26 Sep 2020
First published
28 Sep 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities

C. Gangadurai, G. T. Illa and D. S. Reddy, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01790F

Social activity

Search articles by author

Spotlight

Advertisements