Xiaonan Wang, Yuan Gao, Zhonglin Wei, Jungang Cao, Dapeng Liang, Yingjie Lin and Haifeng Duan
Org. Biomol. Chem., 2020,18, 7431-7436
DOI:
10.1039/D0OB01725F,
Paper
An efficient enantioselective addition of thiols to acyclic trifluoromethyl ketimines has been established by using a bifunctional squaramide catalyst, which was derived from quinine, and the reaction was completed in 5 to 10 min. The construction of chiral tetrasubstituted carbon centers bearing trifluoromethylated N,S-ketals has been achieved in high yields (up to 96% yield) with excellent enantioselectivities (up to 99% ee).
