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Issue 40, 2020
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A directing group free Pd(ii)-catalysed desulfitative C6-arylation of 2-pyridone using an arylsulfonyl chloride

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Abstract

A Pd(II)-catalysed direct desulfitative arylation was realized at the C6-position of the 2-pyridone scaffold. Aryl sulfonyl chloride was used as an alternative arylating agent. The required site-selectivity occurred without the strategic installation of a heteroatom containing directing group. Preliminary mechanistic studies revealed that radical species were involved during this process.

Graphical abstract: A directing group free Pd(ii)-catalysed desulfitative C6-arylation of 2-pyridone using an arylsulfonyl chloride

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Article information


Submitted
19 Aug 2020
Accepted
24 Sep 2020
First published
24 Sep 2020

Org. Biomol. Chem., 2020,18, 8079-8083
Article type
Communication

A directing group free Pd(II)-catalysed desulfitative C6-arylation of 2-pyridone using an arylsulfonyl chloride

U. Karmakar and R. Samanta, Org. Biomol. Chem., 2020, 18, 8079
DOI: 10.1039/D0OB01716G

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