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Issue 40, 2020
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Palladium-catalyzed double coupling reaction of terminal alkynes with isocyanides: a direct approach to symmetrical N-aryl dialkynylimines

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Abstract

A novel and efficient one-pot synthesis of symmetrical N-aryl dialkynylimines via palladium-catalyzed and copper-promoted isocyanide insertion, cross-coupling and elimination has been developed. This method features readily available starting materials, mild reaction conditions and high atom efficiency as well as simple one-pot operation, which make this strategy highly attractive. Moreover, 2-iodobenzo[f]quinoline derivatives can be obtained via electrophilic cyclization of N-aryl dialkynylimines.

Graphical abstract: Palladium-catalyzed double coupling reaction of terminal alkynes with isocyanides: a direct approach to symmetrical N-aryl dialkynylimines

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Article information


Submitted
04 Aug 2020
Accepted
28 Sep 2020
First published
29 Sep 2020

Org. Biomol. Chem., 2020,18, 8089-8093
Article type
Communication

Palladium-catalyzed double coupling reaction of terminal alkynes with isocyanides: a direct approach to symmetrical N-aryl dialkynylimines

Z. Xi, Y. He, L. Liu and Y. Wang, Org. Biomol. Chem., 2020, 18, 8089
DOI: 10.1039/D0OB01604G

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