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Issue 40, 2020
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Organic synthesis of high added value molecules with MOF catalysts

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Abstract

Recent examples of organic synthesis of fine chemicals and pharmaceuticals in confined spaces of MOFs are highlighted and compared with silica-based ordered porous solids, such as zeolites or mesoporous (organo)silica. These heterogeneous catalysts offer the possibility of stabilizing the desired transition states and/or intermediates during organic transformations of functional groups and (C–C/C–N) bond forming steps towards the desired functional high added value molecular scaffolds. A short introduction on zeolites, mesoporous silica and metal–organic frameworks is followed by relevant applications in which confined active sites in the pores promote single or multi-step organic synthesis of industrially relevant molecules. A critical discussion on the catalytic performances of the different types of hybrid inorganic–organic catalysts in the synthesis of O- and N-containing acyclic and heterocyclic molecules has been presented.

Graphical abstract: Organic synthesis of high added value molecules with MOF catalysts

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Article information


Submitted
30 Jul 2020
Accepted
10 Sep 2020
First published
10 Sep 2020

Org. Biomol. Chem., 2020,18, 8058-8073
Article type
Review Article

Organic synthesis of high added value molecules with MOF catalysts

N. Martín and F. G. Cirujano, Org. Biomol. Chem., 2020, 18, 8058
DOI: 10.1039/D0OB01571G

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