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Issue 35, 2020
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Non-hydrogen bond catalyst-mediated diastereoselective conjugate additions of 5H-oxazol-4-ones to o-hydroxyphenyl-substituted p-quinone methides

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Abstract

An efficient DBU-catalyzed conjugate addition of 5H-oxazol-4-ones to o-hydroxyphenyl-substituted p-quinone methides has been developed, affording the valuable diarylmethanes in high yields with excellent diastereoselectivity. This strategy demonstrates a robust access to a wide range of diarylmethane derivatives possessing biologically significant o-hydroxyphenol and p-hydroxyphenol moieties under mild reaction conditions.

Graphical abstract: Non-hydrogen bond catalyst-mediated diastereoselective conjugate additions of 5H-oxazol-4-ones to o-hydroxyphenyl-substituted p-quinone methides

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Supplementary files

Article information


Submitted
29 Jul 2020
Accepted
18 Aug 2020
First published
19 Aug 2020

Org. Biomol. Chem., 2020,18, 6807-6811
Article type
Communication

Non-hydrogen bond catalyst-mediated diastereoselective conjugate additions of 5H-oxazol-4-ones to o-hydroxyphenyl-substituted p-quinone methides

Z. Wang, A. Huang, F. Fang, P. Li, G. Liu and W. Li, Org. Biomol. Chem., 2020, 18, 6807
DOI: 10.1039/D0OB01558J

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